Epidemiology of primary brain tumors in childhood and adolescence in Kuwait
نویسندگان
چکیده
The relatively high frequency of primary brain tumors (PBT) observed in childhood and adolescence in Kuwait has necessitated this epidemiological study. It is based on the records of the Department of Pathology, Al-Sabah Hospital, which examined all brain tumor biopsies done in this age group in Kuwait between 1995 and 2011. During this period, 75 boys (49%) boys and 77 (51%) girls had histologically confirmed PBT. They comprised 122 children (0-14 years) and 30 adolescents (15-19 years). The boys/girls ratio was 1.03 in childhood and 0.76 in adolescence. The age-adjusted incidence rate was 11.2/ million person-years. Early childhood (0-4 years) had the peak frequency of tumors (33%), highest adjusted age-specific incidence rate (3.8/million person-years) of all tumors and the least boys/girls rates ratio (0.38) for astrocytic tumors. Low grade and high grade tumors peaked in 5-9 and 0-4 years respectively. Risk factors (hereditary syndromes or previous radio-therapy) were identified in three patients. Three (2%) tumors were congenital. High grade tumors comprised 47% of childhood and 23% of adolescence PBT. The most common tumors in childhood were astrocytoma (37%), embryonal tumors (31%), ependymoma (8%), and in adolescence astrocytoma (27%), pituitary adenoma (23%) and glioblastoma (13%). Embryonal tumors formed 44% of PBT in early childhood. Gliomas constituted 54% and 43% of all PBT, but 25% and 57% of high grade tumors in childhood and adolescence respectively. Most common tumor locations were cerebellum (47%), ventricles (19%) and cerebral lobes (17%) in childhood and pituitary (30%), cerebellum (27%) and 13% each for cerebral lobes and ventricles in adolescence. Approximately 57% of childhood and 23% of adolescence PBT were infratentorial. In conclusion, despite the high relative frequency of PBT before the age of 20 years in Kuwait, its incidence rate is apparently low. Compared with Western countries, Kuwait has a lower incidence of malignant gliomas, but a higher frequency of cerebellar and intraventricular tumors. Embryonal tumors are remarkably common in early childhood.
منابع مشابه
Clinicopathologic and Survival Characteristics of Childhood and Adolescent Brain and Spinal Cord Tumors in Center of Iran
Background: The brain and spinal cord tumors account for 15% to 20% of all childhood malignancies. It is important to know the epidemiologic characteristics and survival of these patients to better understand the disease and the factors affecting its prognosis. The aim pf this study was to characterize the clinicopathology and survival rate of childhood and adolescent brain and spinal cord tumo...
متن کاملP128: Relationship of Childhood Brain Tumors and Hair Dye Usage During Pregnancy
Brain tumors, which is one of the destructive forms of human being’s cancers, are the second most common children’s cancers. Brain tumors may have an inherited (small percent), acquired reasons due to environmental factors. Nowadays advances in cosmetic industry have increased our ability in the field of youth and beauty. Hair dye products are such innovations. Recent studies showed...
متن کاملA five-year interval study of primary brain tumors in Alzahra Hospital in Esfahan
Background: About half of all brain tumors are primary, and the remainder are metastatic. Tumors of the nervous system have unique characteristics that set them apart from neoplastic processes elsewhere in the body. The World Health Organization (WHO) has classified central nervous system (CNS) tumors as grades I to IV in increasing order of malignancy. The goal of this study was to follow the...
متن کاملGlioblastoma Multiforme in a nine-year-old girl: a case report
Brain tumors are the most common solid tumors in childhood. Glioblastoma multiform (GBM) is the second most common primary brain tumor in adults. It usually affects the cerebral hemispheres of adults at the 6th or 7th decade of life. In comparison to adult population, GBM is rare in pediatrics and accounts for approximately 3% of all pediatric brain tumors. Pediatric glioblastoma was defined as...
متن کاملThe Moderating Role of Cognitive Flexibility in the Relationship Between Maltreatment and Emotion Regulation in Adolescence with Childhood Trauma
Background: Adolescence is a developmental period when adverse childhood experiences have a significant impact due to the changes in brain structure and functioning during this period. This research aimed to investigate the relationship between maltreatment and emotion regulation with moderating role of cognitive flexibility in adolescence with childhood trauma. Methods: This study was a desc...
متن کامل